Kastrup J S, Pilgaard M, Jørgensen F S, Nielsen P E, Rasmussen H
Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Universitetsparken 2, Copenhagen.
FEBS Lett. 1995 Apr 17;363(1-2):115-7. doi: 10.1016/0014-5793(95)00294-j.
Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. PNAs are being intensely investigated owing to a potential as gene-targeted drugs. A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex has been crystallized in a tetragonal space group P4(1)22 with cell dimensions a = b = 79.8, c = 99.9 angstrum. The crystals diffract to about 5 angstrum resolution.
