Nishioka Y
Department of Biology, McGill University, Montréal, Canada.
Genome. 1995 Feb;38(1):1-7. doi: 10.1139/g95-001.
The house mouse is one of the model organisms in genetics and more than 400 inbred strains have been established. However, many of the strains are related and their ancestry can be traced back to European fancy mice inbred in the 1920s. Recent molecular studies corroborate the early historical records that assert that Japanese fancy mice were introduced into European stocks and thus contributed to the development of "old" inbred strains. Consequently, many inbred strains have genomic DNA derived from more than one subspecies of Mus musculus. The subspecific hybrid origin of common inbred strains has important bearings on the interpretation of genetic data, and the limitations that history imposes upon the currently available strains make it necessary to establish new inbred strains representing specific wild populations.
家鼠是遗传学中的模式生物之一，已建立了400多个近交系。然而，许多品系相互关联，其谱系可追溯到20世纪20年代培育的欧洲观赏小鼠。最近的分子研究证实了早期的历史记录，即日本观赏小鼠被引入欧洲种群，从而促进了“老”近交系的发展。因此，许多近交系具有源自小家鼠多个亚种的基因组DNA。常见近交系的亚种杂交起源对遗传数据的解释具有重要影响，历史对现有品系造成的限制使得有必要建立代表特定野生种群的新近交系。
