Vertuani G, Boggian M, Scatturin A, Ricci M, Meli Balbocchino B, Tuttobello L, Rossi C
Dipartimento de Scienze Farmaceutiche, Università di Ferrara, Italy.
J Antibiot (Tokyo). 1995 Mar;48(3):254-60. doi: 10.7164/antibiotics.48.254.
The synthesis and a conformational study of a number of homologues of the well known antibiotic, phytotoxic leucinostatin A are reported. The circular dichroism of all the compounds are discussed. Some conclusions on the SAR of these compounds are drawn. The influence of the alpha-helical conformation and/or the increased lipophile character on their interesting biological activities is emphasized.
报道了一些著名抗生素植物毒性亮抑菌素A同系物的合成及构象研究。讨论了所有化合物的圆二色性。得出了这些化合物构效关系的一些结论。强调了α-螺旋构象和/或增加的亲脂性对其有趣生物活性的影响。
