3-表放线杀菌素的合成与活性
Synthesis and activity of 3-epi-actinobolin.
作者信息
Adachi H, Nishimura Y, Kondo S, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1998 Feb;51(2):202-9. doi: 10.7164/antibiotics.51.202.
PMID:9544942
Abstract
3-epi-Actinobolin was synthesized by the chemical transformation of actinobolin involving a key step of the reconstruction of fused delta-lacton skeleton via intramolecular acylation reaction. The analogue with low toxicity weakly inhibits Gram-positive and Gram-negative bacteria.
摘要
3-表放线菌素通过对放线菌素进行化学转化合成，其中涉及一个关键步骤，即通过分子内酰化反应重建稠合δ-内酯骨架。该类似物毒性低，对革兰氏阳性菌和革兰氏阴性菌有微弱抑制作用。
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