Odegaard A, Lamvik J
Acta Pathol Microbiol Scand C. 1976 Feb;84(1):37-44. doi: 10.1111/j.1699-0463.1976.tb03597.x.
The effect of phenylbutazone and chloramphenicol on the function of blood monocytes cultured in vitro was studied. Both drugs had an inhibitory effect on the engulfment stage of phagocytosis. While a moderate effect only of chloramphenicol on digestion of engulfed yeast particles was found, phenylbutazone caused a marked reduction of the digestion of engulfed particles. Concomitant with this reduction of digestive ability, the lysosomes showed no morphological alterations as observed in control cultures without drug addition, indicating a lack of fusion between the engulged particles and lysosomes in the presence of phenylbutazone.
