Viken K E
Acta Pathol Microbiol Scand C. 1976 Dec;84C(6):465-70. doi: 10.1111/j.1699-0463.1976.tb00056.x.
The in vitro effect of Na-salicylate on some functions of human mononuclear cells was studied. In therapeutical concentrations the drug was found to interfere both the function of lymphocytes and monocytes/macrophages. Na-salicylate in concentrations of 400-800 mug/ml slightly inhibited the digestion of yeast particles. When the drug was present in the culture medium in doses above 160 mug/ml during the cell differentiation period from 90 minutes to the 8th day of culture, a reduction in the number of adhesive, viable cells was recorded. The remaining cells, however, were found to have a normal phagocytic function. A strong and dose dependent inhibition of the ability of lymphocytes to proliferate after antigenic stimulation with BCG bacilli was recorded. The inhibitory effect on the PHA response, however, was less prominent. The results presented indicate that Na-salicylate has a direct inhibitory effect on lymphocyte proliferation and monocyte differentiation and phagocytosis, which may be part of the explanation of the anti-inflammatory effect of the drug.
研究了水杨酸钠对人单核细胞某些功能的体外作用。在治疗浓度下，发现该药物会干扰淋巴细胞以及单核细胞/巨噬细胞的功能。浓度为400 - 800微克/毫升的水杨酸钠会轻微抑制酵母颗粒的消化。当在培养90分钟至培养第8天的细胞分化期，培养基中药物剂量高于160微克/毫升时，记录到黏附的活细胞数量减少。然而，发现其余细胞具有正常的吞噬功能。记录到用卡介苗进行抗原刺激后，淋巴细胞增殖能力受到强烈且剂量依赖性的抑制。然而，对PHA反应的抑制作用不太明显。所呈现的结果表明，水杨酸钠对淋巴细胞增殖、单核细胞分化和吞噬作用具有直接抑制作用，这可能是该药物抗炎作用的部分解释。
