Algvere P, Kock E
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Apr 14;199(2):133-9. doi: 10.1007/BF02385209.
Intravitreal implantation of dermal connective tissue in rabbits caused a fibroplasia resulting in vitreous retraction, retinal detachment, and traction of nervous tissue from the optic nerve into the vitreous space. Following implantation into eyes with an intact vitreous the incidence of retinal detachment was low (2 eyes of 12). When the hyaluronic acid of the vitreous was degraded by hyaluronidase prior to implantation, 9 eyes of 12 developed a progressive detachment of the retina, usually within one or two months. Intravitreal fibroplasia was found to be an important pathogenic factor causing deteachment of the retina.
兔眼玻璃体内植入真皮结缔组织会导致纤维组织增生，进而引起玻璃体后脱离、视网膜脱离以及神经组织从视神经向玻璃体腔的牵拉。将其植入玻璃体完整的眼中时，视网膜脱离的发生率较低（12只眼中有2只）。在植入前用透明质酸酶降解玻璃体中的透明质酸后，12只眼中有9只出现了渐进性视网膜脱离，通常在一两个月内发生。发现玻璃体内纤维组织增生是导致视网膜脱离的一个重要致病因素。
