脂肪酸在蠕孢青霉中蠕孢菌素生物合成中的作用。
Role of aliphatic acids in the biosynthesis of vermiculin in penicillium vermiculatum.
作者信息
Proksa B, Fuska J
机构信息
Slovak Technical University, Faculty of Chemistry, Department of Biochemical Technology, Bratislava.
出版信息
Pharmazie. 1995 Mar;50(3):215-6.
PMID:7732055
Abstract
The diolode macrolide vermiculin (1) together with the three unsaturated aliphatic ketoacids vermiculinic (2), vermiculic (3) and 4-deoxovermiculic acid (4) were isolated from the cultivation broth of Penicillium vermiculatum. Biotransformation of 2 and 3 with growing and resting cells of P. vermiculatum was studied. We suppose, that 2 which is formed from 3, is the ultimate progenitor of 1.
摘要
从蠕孢青霉的培养液中分离出二醇大环内酯蠕霉素（1）以及三种不饱和脂肪族酮酸蠕霉素酸（2）、蠕孢酸（3）和4-脱氧蠕孢酸（4）。研究了用蠕孢青霉的生长细胞和静止细胞对2和3进行生物转化的过程。我们推测，由3形成的2是1的最终前体。
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