Cash J M, Wilder R L
Cleveland Clinic Foundation, Ohio, USA.
Rheum Dis Clin North Am. 1995 Feb;21(1):1-18.
Because rheumatoid arthritis rarely remits, refractory disease is common. Attention should be paid to aggravating comorbid conditions. Pharmacologic options currently available include cyclosporin, high-dose methotrexate, combination second-line agents, and creative use of corticosteroids. The available literature is reviewed in this article and the potential risks and benefits of the various options are discussed.
由于类风湿性关节炎很少缓解，难治性疾病很常见。应注意加重合并症。目前可用的药物选择包括环孢素、高剂量甲氨蝶呤、联合二线药物以及糖皮质激素的创新使用。本文回顾了现有文献，并讨论了各种选择的潜在风险和益处。
