Saeki T, Taneichi K, Shibaki H
Department of internal medicine, Kitami Red Cross Hospital, Hokkaido.
Ryumachi. 1995 Feb;35(1):90-4.
Forty-five-year-old woman with systemic lupus erythematosus who had treated with sulindac had exacerbation of her rash and arthralgia. On her admission for treatment, chest X-ray showed bilateral pathy infiltrates in lower lung fields. We performed a transbronchial lung biopsy. Immunohistopathologic studies showed granular deposits of IgM and C 3 in the subendothelial area of pulmonary arteriolae. She was treated with prednisolone (1.0 mg/kg/day) and deoxyspergualin. Chest X-ray showed improvement and her serum IgG, anti-DNA antibodies and complement diminished quickly. We suggest that these immunopathologic observations may be important in the pathogenesis of the lung injury in systemic lupus erythematosus.
一位45岁患有系统性红斑狼疮的女性，曾接受舒林酸治疗，出现皮疹和关节痛加重。在入院治疗时，胸部X线显示双下肺野有斑片状浸润。我们进行了经支气管肺活检。免疫组织病理学研究显示，在肺小动脉的内皮下区域有IgM和C3的颗粒状沉积。她接受了泼尼松龙（1.0毫克/千克/天）和去氧精胍菌素治疗。胸部X线显示病情改善，她的血清IgG、抗DNA抗体和补体迅速下降。我们认为这些免疫病理学观察结果可能在系统性红斑狼疮肺损伤的发病机制中具有重要意义。
