2,4,6-三硝基甲苯及其微生物代谢产物的毒性和致突变性。
Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
作者信息
Won W D, DiSalvo L H, Ng J
出版信息
Appl Environ Microbiol. 1976 Apr;31(4):576-80. doi: 10.1128/aem.31.4.576-580.1976.
Abstract
TNT (2,4,6-trinitrotoluene) of explosive grade is highly toxic to marine forms that included fresh water unicellular green algae (Selenastrum capricornutum), tidepool copepods (Tigriopus californicus), and oyster larvae (Crassostrea gigas), and mutagenic to Salmonella typhimurium. On the basis of mutagenic assays carried out with a set of histidine-requiring strains of the bacterium, TNT was detected as a frameshift mutagen that significantly accelerates the reversion rate of a frameshift tester, TA-98. In contrast, the major microbial metabolites of TNT appeared to be nontoxic and nonmutagenic.
摘要
爆炸级的三硝基甲苯（TNT）对多种海洋生物具有高毒性，这些生物包括淡水单细胞绿藻（羊角月牙藻）、潮间带桡足类动物（加州虎斑猛水蚤）和牡蛎幼虫（太平洋牡蛎），并且对鼠伤寒沙门氏菌具有致突变性。基于对一组需要组氨酸的该细菌菌株进行的致突变性测定，TNT被检测为一种移码诱变剂，它能显著加速移码测试菌株TA - 98的回复突变率。相比之下，TNT的主要微生物代谢产物似乎无毒且无致突变性。
相似文献
1
Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
Appl Environ Microbiol. 1976 Apr;31(4):576-80. doi: 10.1128/aem.31.4.576-580.1976.
2
[Mutagenic activity of 2,4,6-trinitrotoluene: the role of metabolizing enzymes].
Genetika. 1994 Jul;30(7):898-902.
3
[Dependence of the intensity of 2,4,6-trinitrotoluene-induced mutagenesis on the physiological state of tester strains of Salmonella typhimurium].
Mikrobiologiia. 1996 Jan-Feb;65(1):84-8.
4
Toxic effects of hydroxylamino intermediates from microbial transformation of trinitrotoluene and dinitrotoluenes on algae Selenastrum capricornutum.
Bull Environ Contam Toxicol. 2000 Apr;64(4):579-85. doi: 10.1007/s001280000042.
5
Mutagenicity of tetranitroazoxytoluenes: a preliminary screening in Salmonella typhimurium strains TA100 and TA100NR.
Mutat Res. 1995 Dec;335(3):207-11. doi: 10.1016/0165-1161(95)00022-4.
6
Mutagenicity in Salmonella typhimurium and structure-activity relationships of wastewater components emanating from the manufacture of trinitrotoluene.
Environ Mutagen. 1982;4(2):163-79. doi: 10.1002/em.2860040207.
7
Cytotoxicity and mutagenicity of a 2,4,6-trinitrotoluene (TNT) and hexogen contaminated soil in S. typhimurium and mammalian cells.
Chemosphere. 1998 Jul;37(2):209-18. doi: 10.1016/s0045-6535(98)00039-3.
8
Screening for soil toxicity and mutagenicity using luminescent bacteria--a case study of the explosive 2,4,6-trinitrotoluene (TNT).
Ecotoxicol Environ Saf. 2002 Feb;51(2):133-44. doi: 10.1006/eesa.2001.2124.
9
Mutagenicity of HPLC-fractionated urinary metabolites from 2,4,6-trinitrotoluene-treated Fischer 344 rats.
Environ Mol Mutagen. 1997;30(3):298-302.
10
Genotoxicity and potential carcinogenicity of 2,4,6-TNT trinitrotoluene: structural and toxicological considerations.
Rev Environ Health. 2006 Oct-Dec;21(4):217-28. doi: 10.1515/reveh.2006.21.4.217.
引用本文的文献
1
Machine Learning Models for High Explosive Crystal Density and Performance.
Chem Mater. 2024 Nov 7;36(22):11109-11118. doi: 10.1021/acs.chemmater.4c01978. eCollection 2024 Nov 26.
2
Ecotoxicological Risk of World War Relic Munitions in the Sea after Low- and High-Order Blast-in-Place Operations.
Environ Sci Technol. 2023 Dec 5;57(48):20169-20181. doi: 10.1021/acs.est.3c04873. Epub 2023 Nov 7.
3
Genotoxicity assessment of acute exposure of 2, 4-dinitroanisole, its metabolites and 2, 4, 6-trinitrotoluene to Daphnia carinata.
Ecotoxicology. 2016 Dec;25(10):1873-1879. doi: 10.1007/s10646-016-1709-8. Epub 2016 Sep 20.
4
Enhanced transformation of TNT by Arabidopsis plants expressing an old yellow enzyme.
PLoS One. 2012;7(7):e39861. doi: 10.1371/journal.pone.0039861. Epub 2012 Jul 11.
5
Enhanced degradation of TNT by genome-shuffled Stenotrophomonas maltophilia OK-5.
Curr Microbiol. 2009 Sep;59(3):346-51. doi: 10.1007/s00284-009-9443-6. Epub 2009 Jun 20.
6
Structure-toxicity relationships of nitroaromatic compounds.
Mol Divers. 2006 May;10(2):233-45. doi: 10.1007/s11030-005-9002-4. Epub 2006 May 19.
7
Structure of a laccase-mediated product of coupling of 2,4-diamino-6-nitrotoluene to guaiacol, a model for coupling of 2,4,6-trinitrotoluene metabolites to a humic organic soil matrix.
Appl Environ Microbiol. 1997 Jul;63(7):2560-5. doi: 10.1128/aem.63.7.2560-2565.1997.
8
Transformation of 2,4,6-Trinitrotoluene by Pseudomonas pseudoalcaligenes JS52.
Appl Environ Microbiol. 1997 May;63(5):2007-15. doi: 10.1128/aem.63.5.2007-2015.1997.
9
Changes in toxicity and genotoxicity of industrial sewage sludge samples containing nitro- and amino-aromatic compounds following treatment in bioreactors with different oxygen regimes.
Environ Sci Pollut Res Int. 2004;11(5):313-20. doi: 10.1007/BF02979645.
10
Biodegradation of nitro-substituted explosives 2,4,6-trinitrotoluene, hexahydro-1,3,5-trinitro-1,3,5-triazine, and octahydro-1,3,5,7-tetranitro-1,3,5-tetrazocine by a phytosymbiotic Methylobacterium sp. associated with poplar tissues (Populus deltoides x nigra DN34).
Appl Environ Microbiol. 2004 Jan;70(1):508-17. doi: 10.1128/AEM.70.1.508-517.2004.
本文引用的文献
1
The metabolism of 2:4:6-trinitrotoluene (alpha-T.N.T.).
Biochem J. 1944;38(1):70-85. doi: 10.1042/bj0380070.
2
Acetylornithinase of Escherichia coli: partial purification and some properties.
J Biol Chem. 1956 Jan;218(1):97-106.
3
Metabolic disposition of 2,4,6-trinitrotoluene.
Appl Microbiol. 1974 Mar;27(3):513-6. doi: 10.1128/am.27.3.513-516.1974.
4
An improved bacterial test system for the detection and classification of mutagens and carcinogens.
Proc Natl Acad Sci U S A. 1973 Mar;70(3):782-6. doi: 10.1073/pnas.70.3.782.
5
Salmonella typhimurium hisG46 (R-Utrecht): possible use in screening mutagens and carcinogens.
Appl Microbiol. 1973 Dec;26(6):1004-5. doi: 10.1128/am.26.6.1004-1005.1973.
6
Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2281-5. doi: 10.1073/pnas.70.8.2281.
7
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
Proc Natl Acad Sci U S A. 1975 Mar;72(3):979-83. doi: 10.1073/pnas.72.3.979.
Zotero 插件