Lundberg T, Eriksson A S, Kahnberg K E, Thomsen P
Department of Oral and Maxillofacial Surgery, University of Gothenburg, Sweden.
Biomaterials. 1995 Jan;16(2):107-11. doi: 10.1016/0142-9612(95)98271-f.
The acute inflammatory reaction elicited after implantation of polymer membranes used clinically to promote bone healing and augmentation was studied in a soft tissue titanium chamber model. The two materials compared were non-degradable expanded polytetrafluoroethylene (ePTFE) and degradable polyglactin 910, a copolymer of 90% polyglycolic acid and 10% polylactic acid. The membranes were implanted in the titanium chamber for 24 h and 6 d. The number of leucocytes increased for both materials, whereas the leukotriene B4 (LTB4) content decreased over time. In both groups polymorphonuclear granulocytes predominated. The number of leucocytes was significantly higher in chambers with polyglactin 910 than ePTFE. In contrast, the LTB4 content was higher in chambers with ePTFE than polyglactin 910. No differences in cell viability were observed between the materials tested. This study shows that both degradable and non-degradable polymers elicit a marked influx and activation of inflammatory cells during early healing in soft tissues.
在软组织钛腔模型中，研究了临床上用于促进骨愈合和骨增量的聚合物膜植入后引发的急性炎症反应。所比较的两种材料分别是不可降解的膨体聚四氟乙烯（ePTFE）和可降解的聚乳酸910，它是由90%的聚乙醇酸和10%的聚乳酸组成的共聚物。将这些膜植入钛腔24小时和6天。两种材料的白细胞数量均增加，而白三烯B4（LTB4）含量随时间下降。两组中均以多形核粒细胞为主。聚乳酸910所在腔室中的白细胞数量显著高于ePTFE所在腔室。相反，ePTFE所在腔室中的LTB4含量高于聚乳酸910所在腔室。在所测试的材料之间未观察到细胞活力的差异。这项研究表明，可降解和不可降解的聚合物在软组织早期愈合过程中均引发炎症细胞的显著流入和激活。
