Taimela S, Viikari J S, Porkka K V, Dahlen G H
Helsinki Research Institute for Sports and Exercise Medicine, Finland.
Acta Paediatr. 1994 Dec;83(12):1258-63. doi: 10.1111/j.1651-2227.1994.tb13009.x.
A high lipoprotein(a) (Lp(a)) level is an independent and predominantly genetically determined risk factor for coronary heart disease and other vascular diseases. We studied the levels of Lp(a) and the influence of physical activity on Lp(a) in the young Finnish population. The study cohort comprised children and young adults aged 9, 12, 15, 18, 21 and 24 years (n = 2464) participating in a large multicenter follow-up study of cardiovascular risk factors in children and young adults. Data were available on physical activity, anthropometric variables, serum Lp(a), insulin and lipid levels. A physical activity index was calculated based on several physical activity variables. Lp(a) was determined by radioimmunoassay with a detection threshold of 3 mg/dl. Differences were assessed with non-parametric statistical analyses. The observed range of Lp(a) was from < 3 to 90.8 mg/dl. The distribution of Lp(a) was highly skewed as 88% of the population (89% males and 87% females) had Lp(a) concentrations less than 25 mg/dl. A total of 35% of the subjects had Lp(a) levels less than 3 mg/dl. There were no significant differences in Lp(a) levels with respect to age or gender. The serum concentration of Lp(a) was statistically significantly correlated with the level of physical activity. Other behavioral variables studied did not have a significant contribution to the variability of Lp(a) levels. These results demonstrate that levels of Lp(a) are not related to age, gender or many of the known coronary heart disease risk factors. However, physical activity is associated with favorable Lp(a) levels, as high levels of Lp(a) (> 25 mg/dl) were less frequent in the physically most active subjects.
高脂蛋白(a)[Lp(a)]水平是冠心病和其他血管疾病独立的、主要由遗传决定的危险因素。我们研究了芬兰年轻人群中Lp(a)水平以及体育活动对Lp(a)的影响。研究队列包括9岁、12岁、15岁、18岁、21岁和24岁的儿童及年轻人（n = 2464），他们参与了一项关于儿童及年轻人心血管危险因素的大型多中心随访研究。可获取体育活动、人体测量学变量、血清Lp(a)、胰岛素和血脂水平的数据。基于多个体育活动变量计算出体育活动指数。Lp(a)通过放射免疫测定法测定，检测阈值为3mg/dl。采用非参数统计分析评估差异。观察到的Lp(a)范围为<3至90.8mg/dl。Lp(a)的分布高度偏态，因为88%的人群（89%男性和87%女性）Lp(a)浓度低于25mg/dl。共有35%的受试者Lp(a)水平低于3mg/dl。Lp(a)水平在年龄或性别方面无显著差异。血清Lp(a)浓度与体育活动水平在统计学上显著相关。所研究的其他行为变量对Lp(a)水平的变异性无显著贡献。这些结果表明，Lp(a)水平与年龄、性别或许多已知的冠心病危险因素无关。然而，体育活动与有利的Lp(a)水平相关，因为在体育活动量最大的受试者中，高水平的Lp(a)（>25mg/dl）出现频率较低。
