Douglas-Jones A P, Cruickshank J M
Br Med J. 1976 Apr 24;1(6016):990-1. doi: 10.1136/bmj.1.6016.990.
Because of the difficulties patients have in adhering to their drug regimens a trial was performed in which patients with essential hypertension were given, in random order and for four weeks each, three different doses of atenolol to be taken once daily. Atenolol effectively decreased lying and standing blood pressures, and there was no difference between the effects of the three doses. The simplicity of the regimen, as well as atenolol's freedom from troublesome side effects, should be valuable in helping patients adhere to long-term treatment.
由于患者在坚持药物治疗方案方面存在困难，因此进行了一项试验，对原发性高血压患者随机给予三种不同剂量的阿替洛尔，每种剂量服用四周，每日一次。阿替洛尔能有效降低卧位和立位血压，三种剂量的效果无差异。该治疗方案的简单性以及阿替洛尔无不良副作用，对于帮助患者坚持长期治疗应具有重要价值。
