Chirakal R, Adams R M, Firnau G, Schrobilgen G J, Coates G, Garnett E S
Department of Nuclear Medicine, Chedoke-McMaster Hospitals, Hamilton, Ontario, Canada.
Nucl Med Biol. 1995 Jan;22(1):111-6. doi: 10.1016/0969-8051(94)e0064-p.
Because more and more PET centres are using small proton cyclotrons there is a renewed interest in methods for the production of electrophilic 18F by proton irradiation of [18O]O2. A method for the routine production of clinically useful quantities of [18F]F2 having a specific activity of 35 Ci/mmol has been developed and implemented using an 11 MeV proton cyclotron and [18O]O2. Based on the yield, purity, reproducibility, and specific activity of [18F]F2 this is the most efficient method reported thus far.
由于越来越多的正电子发射断层扫描（PET）中心开始使用小型质子回旋加速器，通过用质子辐照[18O]O2来生产亲电18F的方法重新引起了人们的关注。利用一台11兆电子伏质子回旋加速器和[18O]O2，已开发并实施了一种常规生产具有35居里/毫摩尔比活度的临床可用量[18F]F2的方法。基于[18F]F2的产率、纯度、重现性和比活度，这是迄今为止报道的最有效的方法。
