Nishiyama N, Moriguchi T, Saito H
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Exp Gerontol. 1997 Jan-Apr;32(1-2):149-60. doi: 10.1016/s0531-5565(96)00062-9.
We first investigated the effect of aged garlic extract (AGE) on the longevity and learning performance in the Senescence-Accelerated Mouse (SAM). A solid diet containing AGE was fed after two months of age. An AGE treatment increased the survival ratio of the SAMP8. Moreover, the preparation ameliorated the memory acquisition deficit and the memory retention impairment of the SAMP8 at 10 months old. The learning improvement was also confirmed in a spatial cognition test. We next studied the effect of AGE on another strain of the SAM, SAMP10. Although the life span prolongation was not observed in the AGE-treated SAMP10, the preparation improved the grading score, an index of aging. A surprising result was obtained by measuring the brain size. The degree of shrinkage in the frontal cerebrum was 2-9% in the SAMP10. Chronic ingestion of AGE prevented this atrophy and kept the brain size at the control level. These results suggest that AGE has an antiaging effect on the SAM.
我们首先研究了 aged garlic extract (AGE, aged garlic extract 可译为“ aged garlic extract”,也可译为“陈蒜提取物”,这里保留英文未译) 对衰老加速小鼠 (SAM) 的寿命和学习能力的影响。在小鼠两个月大后,给它们喂食含有 AGE 的固体饮食。AGE 处理提高了 SAMP8 的存活率。此外,该制剂改善了 10 月龄 SAMP8 的记忆获取缺陷和记忆保持损伤。在空间认知测试中也证实了学习能力的提高。接下来,我们研究了 AGE 对另一品系的 SAM,即 SAMP10 的影响。虽然在接受 AGE 处理的 SAMP10 中未观察到寿命延长,但该制剂改善了衰老指标分级评分。通过测量脑大小获得了一个惊人的结果。SAMP10 额叶大脑的萎缩程度为 2 - 9%。长期摄入 AGE 可防止这种萎缩,并使脑大小保持在对照水平。这些结果表明 AGE 对 SAM 具有抗衰老作用。