Mizokami Y, Tamura K, Fukuda Y, Yamamoto I, Shimoyama T
Department of Internal Medicine 4, Hyogo College of Medicine, Japan.
Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S109-12.
To clarify the relationship between non-steroidal anti-inflammatory drug (NSAID)-associated gastroduodenal mucosal injury and Helicobacter pylori infection.
The incidence of H. pylori infection was determined in a group of patients treated with NSAID for rheumatoid arthritis for > or = 3 months and in a control group of patients with mainly abdominal symptoms but without rheumatoid arthritis and not being treated with NSAID. The incidence of H. pylori infection was also determined in patients treated with different NSAID and antirheumatic drugs. In addition, the minimum inhibitory concentration of several NSAID against H. pylori was investigated.
The incidence of H. pylori infection in the NSAID group tended to be lower than in the control group, and was significantly lower in patients with gastric ulcers. The incidence of infection did not differ between patients treated with one or with more than one NSAID. Differences in the infection rate were found between individual NSAID, with indomethacin being associated with a particularly low rate. No differences in the infection rate were found between different antirheumatic drugs. The minimum inhibitory concentration of ibuprofen was low.
H. pylori appears to have little effect on gastroduodenal mucosal injury associated with long-term NSAID administration.
阐明非甾体抗炎药（NSAID）相关的胃十二指肠黏膜损伤与幽门螺杆菌感染之间的关系。
测定一组接受NSAID治疗类风湿关节炎≥3个月的患者以及一组主要有腹部症状但无类风湿关节炎且未接受NSAID治疗的对照患者中幽门螺杆菌感染的发生率。还测定了接受不同NSAID和抗风湿药物治疗的患者中幽门螺杆菌感染的发生率。此外，研究了几种NSAID对幽门螺杆菌的最低抑菌浓度。
NSAID组中幽门螺杆菌感染的发生率倾向于低于对照组，且胃溃疡患者中的发生率显著更低。使用一种或多种NSAID治疗的患者之间感染发生率无差异。不同NSAID之间发现感染率存在差异，吲哚美辛的感染率尤其低。不同抗风湿药物之间未发现感染率有差异。布洛芬的最低抑菌浓度较低。
幽门螺杆菌似乎对长期服用NSAID相关的胃十二指肠黏膜损伤影响不大。
