Crabtree J E, Lindley I J
Department of Clinical Medicine, St James's University Hospital, Leeds, UK.
Eur J Gastroenterol Hepatol. 1994 Dec;6 Suppl 1:S33-8.
To review the role of interleukin (IL)-8 in the immunopathology of Helicobacter pylori-associated gastroduodenal disease.
Literature review.
In H. pylori infection, IL-8 secretion by the gastric mucosa is increased, particularly in patients with active neutrophilic gastritis. Immunoreactive IL-8 is evident in the epithelium of histologically normal gastric mucosa but epithelial IL-8 expression is increased in H. pylori-associated chronic gastritis. Gastric epithelial cell lines constitutively express IL-8 messenger (m)RNA and IL-8 message and protein secretion can be upregulated by the cytokines tumour necrosis factor-alpha, IL-1 alpha and IL-1 beta. H. pylori also directly induces epithelial IL-8 expression in a strain-specific manner. Cytotoxic strains expressing the CagA protein upregulate IL-8 mRNA and IL-8 protein secretion.
IL-8 is an important chemotactic and activating factor for neutrophils. The secretion of IL-8 by epithelial cells is probably a key factor in host defences at mucosal sites, permitting a rapid polymorph response against infectious agents. If defence mechanisms fail and chronic infection results, continued upregulation of IL-8 and neutrophil activation could lead to mucosal damage and increased free radical formation. Mucosal IL-8 production in H. pylori infection may be an important factor in the immunopathogenesis of peptic ulcer disease and also be of relevance to gastric carcinogenesis.
综述白细胞介素（IL）-8在幽门螺杆菌相关胃十二指肠疾病免疫病理学中的作用。
文献综述。
在幽门螺杆菌感染中，胃黏膜的IL-8分泌增加，尤其是在活动性嗜中性粒细胞性胃炎患者中。免疫反应性IL-8在组织学正常的胃黏膜上皮中明显可见，但在幽门螺杆菌相关的慢性胃炎中上皮IL-8表达增加。胃上皮细胞系组成性表达IL-8信使（m）RNA，细胞因子肿瘤坏死因子-α、IL-1α和IL-1β可上调IL-8信使及蛋白分泌。幽门螺杆菌还以菌株特异性方式直接诱导上皮IL-8表达。表达CagA蛋白的细胞毒性菌株上调IL-8 mRNA和IL-8蛋白分泌。
IL-8是中性粒细胞重要的趋化和激活因子。上皮细胞分泌IL-8可能是黏膜部位宿主防御的关键因素，可使机体对感染因子迅速产生多形核反应。如果防御机制失败并导致慢性感染，IL-8的持续上调和中性粒细胞激活可能导致黏膜损伤和自由基形成增加。幽门螺杆菌感染时黏膜IL-8的产生可能是消化性溃疡疾病免疫发病机制中的一个重要因素，也与胃癌发生有关。
