Yurchenco J A, Hopper M W, Vince T D, Warren G H
Chemotherapy. 1976;22(3-4):232-41. doi: 10.1159/000221930.
Amide penicillin Wy-12,556 and DBED penicillin were studied for their antibacterial effect in CD-1 mice repeatedly infected with Streptococcus pyogenes C203 and/or Staphylococcus aureus Smith. Animals infected with S. aureus Smith failed to show a difference between the therapeutic activity of DBED penicillin and Wy-12,556. Wy-12,556 was significantly more effective than DBED penicillin in protecting the animals challenged repeatedly with S. pyogenes C203. Wy-12,556 provoked a positive transient chemotactic response in uninfected mice. 24 h after intraperitoneal challenge the exudate showed a high neutrophilic count.
对酰胺青霉素Wy - 12,556和DBED青霉素在反复感染化脓性链球菌C203和/或金黄色葡萄球菌史密斯的CD - 1小鼠中的抗菌效果进行了研究。感染金黄色葡萄球菌史密斯的动物未显示出DBED青霉素和Wy - 12,556的治疗活性有差异。在保护反复受到化脓性链球菌C203攻击的动物方面，Wy - 12,556比DBED青霉素显著更有效。Wy - 12,556在未感染的小鼠中引发了阳性短暂趋化反应。腹腔注射攻击24小时后，渗出液显示出高嗜中性粒细胞计数。
