Wallace J L
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, AB, Canada.
Can J Physiol Pharmacol. 1994 Dec;72(12):1493-8. doi: 10.1139/y94-215.
Nonsteroidal anti-inflammatory drugs are widely used for the treatment of osteoarthritis and rheumatoid arthritis, but their ability to cause gastrointestinal bleeding is a significant limitation to this use. A better understanding of the pathogenesis of gastric and intestinal injury induced by these agents will permit the rational design of anti-inflammatory drugs that spare the gastrointestinal tract. In this review, the mechanisms through which nonsteroidal anti-inflammatory drugs are believed to cause gastrointestinal ulceration are reviewed. Several strategies that are being employed to develop gastrointestinal-sparing drugs are outlined.
非甾体抗炎药被广泛用于治疗骨关节炎和类风湿性关节炎，但其导致胃肠道出血的能力严重限制了其在这方面的应用。更好地了解这些药物引起胃肠道损伤的发病机制，将有助于合理设计出能避免胃肠道损伤的抗炎药物。在这篇综述中，我们将回顾非甾体抗炎药被认为导致胃肠道溃疡的机制。同时概述目前正在采用的几种开发保护胃肠道药物的策略。
