Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Clin Geriatr Med. 2012 May;28(2):273-86. doi: 10.1016/j.cger.2012.01.007.
The population of older adults continues to increase, and polypharmacy in this population is more the rule than the exception. Physiologic changes that occur with aging result in multiple alterations to the pharmacokinetics and pharmacodynamics of drugs, which, in turn, increase the risk of adverse drug reactions. Consideration of initial dose adjustment, along with frequent medication reconciliation and analysis of the medication list, are keys to providing optimal pharmaceutical care for elderly patients.
老年人的人口不断增加，在这个人群中，同时使用多种药物治疗更为常见。随着年龄的增长，生理变化会导致药物的药代动力学和药效学发生多种改变，从而增加药物不良反应的风险。考虑初始剂量调整，以及经常进行药物重整和药物清单分析，是为老年患者提供最佳药物治疗的关键。
