Richter-Levin G, Errington M L, Maegawa H, Bliss T V
Division of Neurophysiology and Neuropharmacology, National Institute for Medical Research, London, U.K.
Neuropharmacology. 1994 Jul;33(7):853-7. doi: 10.1016/0028-3908(94)90181-3.
We have examined the effects of the metabotropic glutamate receptor antagonist (RS)-a-methyl-4-carboxyphenylglycine (MCPG) on performance in the water maze, and on LTP in the dentate gyrus, MCPG (5 mM) reversibly blocked the induction of LTP in the perforant path-granule cell projection when perfused into the dentate gyrus of the anaesthetized rat. When injected bilaterally into the lateral ventricles, MCPG (20 mM) disrupted the performance of rats in a spatial learning version of the water maze task. In a terminal experiment, when tetanic stimulation was given to the perforant path, LTP, was found to be significantly reduced in MCPG-injected rats compared to control rats injected with vehicle. These experiments indicate that activation of MCPG-sensitive metabotropic glutamate receptors is necessary both for the full expression of LTP and spatial learning, and supply further evidence for the hypothesis that LTP provides synaptic mechanism for certain forms of learning.
我们研究了代谢型谷氨酸受体拮抗剂（RS）-α-甲基-4-羧基苯甘氨酸（MCPG）对水迷宫实验表现以及齿状回长时程增强（LTP）的影响。当将5 mM的MCPG灌注到麻醉大鼠的齿状回时，它可逆地阻断了穿通通路-颗粒细胞投射中LTP的诱导。当双侧注射20 mM的MCPG到侧脑室时，MCPG破坏了大鼠在水迷宫任务空间学习版本中的表现。在一项终末实验中，当对穿通通路给予强直刺激时，发现与注射赋形剂的对照大鼠相比，注射MCPG的大鼠的LTP显著降低。这些实验表明，MCPG敏感的代谢型谷氨酸受体的激活对于LTP的完全表达和空间学习都是必需的，并为LTP为某些形式的学习提供突触机制这一假说提供了进一步的证据。
