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持续监测五肽胃泌素对人体固体食物胃排空的影响。

Continuous monitoring of the effect of pentagastrin on gastric emptying of solid food in man.

作者信息

Hamilton S G, Sheiner H J, Quinlan M F

出版信息

Gut. 1976 Apr;17(4):273-9. doi: 10.1136/gut.17.4.273.

DOI:10.1136/gut.17.4.273
PMID:773788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411107/
Abstract

By continuous monitoring of a solid meal labelled with a radiopharmaceutical it has been possible to determine the effects of drugs on gastric emptying and motility during a single study. Predictably hyoscine delayed, and bethanechol increased, the rate of gastric emptying. Pentagastrin initially produced marked antral activity resulting in a physiological stricture and subsequent delay in the overall rate of gastric emptying. Fundal motility was unaffected though reflux from the antrum occurred.

摘要

通过持续监测用放射性药物标记的固体餐，可以在单次研究中确定药物对胃排空和动力的影响。不出所料，东莨菪碱延迟了胃排空速率，而氨甲酰甲胆碱则加快了胃排空速率。五肽胃泌素最初产生明显的胃窦活动，导致生理性狭窄，随后胃排空总速率延迟。尽管发生了胃窦反流，但胃底动力未受影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc0/1411107/f7e198b5799b/gut00485-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc0/1411107/535c23369772/gut00485-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc0/1411107/f7e198b5799b/gut00485-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc0/1411107/535c23369772/gut00485-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fc0/1411107/f7e198b5799b/gut00485-0044-a.jpg

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本文引用的文献

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Gastric secretion and emptying before and after vagotomy and pyloroplasty, with and without continuous infusion of peptavlon pentagastrin.迷走神经切断术和幽门成形术前后，在持续输注五肽胃泌素和未持续输注五肽胃泌素的情况下的胃分泌及排空情况。
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