Higuchi T, Odano I, Takahashi N, Sakai K
Department of Radiology, Niigata University School of Medicine.
Kaku Igaku. 1995 Mar;32(3):235-40.
Double injection method using brain perfusion 99mTc-HMPAO SPECT is popular one for evaluating stress scintigraphy. For appropriate evaluation of this method 555 MBq (15 mCi) of 99mTc-HMPAO was injected twice in sequence at the resting state. The first and second SPECT images were obtained 5 min after each injection. Twenty-five ROIs of 8 x 8 pixels were placed on in various regions of the first images, and calculate each counts (C1). Then the counts of the same region of the second scan were calculated (C2). One hundred and fifty ROIs/6 patients were examined. We derived the linear relationship as C2 = 1.66 x C1 + 106 (r = 0.97), where C1 and C2 represents counts of the first scan, and second scan, respectively. This results suggests that the counts of the second scan is derived from the counts of the first scan without second scanning if they are obtained in the same condition. When we applied this method to stress scintigraphy, it may be useful for evaluating the regional brain perfusion changes before and after loading instead of using subtraction technique.
采用脑灌注99mTc - HMPAO单光子发射计算机断层扫描（SPECT）的双注射法是评估应激闪烁显像的常用方法。为了对该方法进行恰当评估，在静息状态下依次注射两次555 MBq（15 mCi）的99mTc - HMPAO。每次注射后5分钟获取首次和第二次SPECT图像。在首次图像的各个区域放置25个8×8像素的感兴趣区（ROI），并计算每个区域的计数（C1）。然后计算第二次扫描相同区域的计数（C2）。共检查了6例患者的150个ROI。我们得出线性关系为C2 = 1.66×C1 + 106（r = 0.97），其中C1和C2分别代表首次扫描和第二次扫描的计数。该结果表明，如果在相同条件下获取，第二次扫描的计数可由首次扫描的计数得出，无需进行第二次扫描。当我们将此方法应用于应激闪烁显像时，它可能有助于评估负荷前后的局部脑灌注变化，而无需使用减法技术。
