Martín M C, Gómez-Jiménez J, Esteban F, Saurí R, Mourelle M I, Salgado A
Unidad de Cuidados Intensivos, Hospital General Universitari Vall d'Hebron, Universidad Autónoma de Barcelona.
Med Clin (Barc). 1995 Apr 1;104(12):458-60.
The plasma levels of endotoxin, tumor necrosis factor- alpha (TNF-alpha), interleukin -1 beta (IL-beta), IL-6, IL-8 and the nitrites and nitrates (NO2-/NO3-) as stable metabolites of nitric oxide (NO) were studied in the plasma of 2 patients with the streptococci toxic shock syndrome (STSS) associated to necrotizing fasciitis. A plasma profile of inflammatory mediators with high cytokine concentrations and NO2-/NO3- were observed with circulating endotoxin not being detected in plasma. The first patient died of fulminant refractory shock while the second survived following subacute evolution. The mediators profile, which was much higher in the first case, coincided with clinical severity. These data suggest that the cytokines and NO may have a role in the physiopathology of STSS and the severity of it is related to the levels of these mediators in the acute phase.
在2例与坏死性筋膜炎相关的链球菌中毒性休克综合征（STSS）患者的血浆中，研究了内毒素、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-β）、IL-6、IL-8以及作为一氧化氮（NO）稳定代谢产物的亚硝酸盐和硝酸盐（NO2-/NO3-）的血浆水平。观察到炎症介质的血浆谱，细胞因子浓度高且有NO2-/NO3-，而血浆中未检测到循环内毒素。第一名患者死于暴发性难治性休克，而第二名患者在亚急性病程后存活。在第一种情况下高得多的介质谱与临床严重程度相符。这些数据表明，细胞因子和NO可能在STSS的病理生理过程中起作用，其严重程度与急性期这些介质的水平有关。
