Kowalczuk C I, Robbins L, Thomas J M, Saunders R D
National Radiological Protection Board, Didcot, Oxon, UK.
Mutat Res. 1995 May;328(2):229-37. doi: 10.1016/0027-5107(95)00012-8.
The potential mutagenicity of power frequency magnetic fields was investigated using a dominant lethal assay in mice. A total of 42 male mice were exposed for 8 weeks to a 50 Hz sinusoidal magnetic field at 10 mT (rms) and 47 males acted as simultaneous cage controls. Each male was subsequently mated with two females on weeks 1, 3, 5, 7, and 9 post-exposure. The numbers of pregnant females, corpora lutea, and live and dead implants were recorded. Multiple logistic regression analyses examined the effects of exposure on pregnancy rate, pre-implantation survival and post-implantation survival. There were no statistically significant differences in overall response between exposed and control groups, nor was there any significant effect of exposure in any post-exposure week. Thus, exposure to power frequency magnetic fields at 10 mT for the approximate period of spermatogenesis did not appear to induce dominant lethal mutation in the germ cells of male mice.
使用小鼠显性致死试验研究了工频磁场的潜在致突变性。总共42只雄性小鼠暴露于10 mT（均方根值）的50 Hz正弦磁场中8周，47只雄性小鼠作为同期笼养对照。随后，在暴露后的第1、3、5、7和9周，每只雄性小鼠与两只雌性小鼠交配。记录怀孕雌性的数量、黄体数量以及存活和死亡的植入物数量。多元逻辑回归分析研究了暴露对妊娠率、植入前存活率和植入后存活率的影响。暴露组和对照组之间的总体反应没有统计学上的显著差异，在任何暴露后周也没有暴露的显著影响。因此，在精子发生的大约时期暴露于10 mT的工频磁场似乎不会在雄性小鼠的生殖细胞中诱导显性致死突变。
