Nesher G, Zuckner J
Department of Internal Medicine, St. Louis University Health Sciences Center, MO 63104, USA.
Semin Arthritis Rheum. 1995 Feb;24(4):291-6. doi: 10.1016/s0049-0172(95)80039-5.
Retinoids are synthetic derivatives of vitamin A. They are administered primarily for dermatological conditions, such as psoriasis, acne, and disorders of keratinization. Toxicity has proven a significant problem with long-term administration of the retinoids. Bone abnormalities mimicking seronegative spondyloarthropathy or diffuse idiopathic skeletal hyperostosis have been described in many cases, as well as other rheumatologic manifestations such as arthritis, myopathy, and vasculitis. These retinoid-related adverse effects are reviewed.
维甲酸是维生素A的合成衍生物。它们主要用于治疗皮肤病，如牛皮癣、痤疮和角化异常。长期服用维甲酸已被证明存在严重的毒性问题。许多病例中都描述了类似血清阴性脊柱关节病或弥漫性特发性骨肥厚的骨骼异常，以及其他风湿病表现，如关节炎、肌病和血管炎。本文对这些与维甲酸相关的不良反应进行了综述。
