Sály J, Kacmár P, Neuschl J, Jantosovic J
University Veterinary Medicine, Kosice, Slovak Republic.
Vet Med (Praha). 1995 Feb;40(2):49-52.
Hematological changes at poisoning with the bentazone herbicide manufactured by the Research Institute of Chemical Technology in Bratislava were investigated in sheep of the Slovak Merino breed. Acute intoxication in seven head of sheep was induced by a single application of bentazone with cannula at a sublethal dose of 1,450 mg/kg live weight. Bentazone was diluted with sunflower oil at a ratio 1:5. Subchronic intoxication was induced by an administration of bentazone in feed to the sheep for 84 days: a dose of 175 mg/kg live weight (1/10 of LD50) for the first experimental group (six head), and a dose of 97.5 mg/kg live weight (1/12 of LD50) for the second experimental group (six head). The control group did not receive any dietary bentazone. Acute intoxication with herbicide did not cause any statistically significant changes in hemoglobin, erythrocyte and leucocyte counts in the sheep within 120 hours after application. In comparison with the physiological standard, a slight increase in the percentage of neutrophils and a decrease in the lymphocyte percentage were observed. The values of eosinophils, basophils and monocytes remained unchanged. Observation of subchronic intoxication did not reveal any significant negative effect of the two doses of the herbicide within 84 days on the hematological parameters. Our experiments demonstrate that bentazone does not negatively influence blood formation.
对布拉迪斯拉发化学技术研究所生产的苯达松除草剂中毒时的血液学变化，在斯洛伐克美利奴品种绵羊中进行了研究。通过用插管以1450毫克/千克体重的亚致死剂量单次施用苯达松，诱导7只绵羊急性中毒。苯达松用向日葵油按1:5的比例稀释。通过在饲料中给绵羊施用苯达松84天诱导亚慢性中毒：第一实验组（6只）剂量为175毫克/千克体重（LD50的1/10），第二实验组（6只）剂量为97.5毫克/千克体重（LD50的1/12）。对照组未接受任何含苯达松的饲料。除草剂急性中毒在施用后120小时内未引起绵羊血红蛋白、红细胞和白细胞计数的任何统计学显著变化。与生理标准相比，观察到中性粒细胞百分比略有增加，淋巴细胞百分比下降。嗜酸性粒细胞、嗜碱性粒细胞和单核细胞的值保持不变。亚慢性中毒观察未发现这两个剂量的除草剂在84天内对血液学参数有任何显著负面影响。我们的实验表明苯达松对血液生成没有负面影响。
