Elkayam O, Tamir R, Pick A I, Wysenbeek A
Division of Clinical Immunology and Allergy, Beilinson Medical Center, Tel Aviv, Israel.
Allergy. 1995 Jan;50(1):94-6.
We investigated the relationship between disease activity and total IgE concentration in the sera of patients with active systemic lupus erythematosus (SLE). In addition, the prevalence of personal and family history of allergic rhinitis and asthma were examined with a questionnaire and immediate skin tests for common inhalant allergens in 24 patients in remission. In the 20 patients with active disease, we found that IgE concentration was significantly higher during the periods of active disease than the periods of remission. This elevation was not associated with an elevation in total serum IgG concentrations. The increase in IgE concentration during disease activity in patients with active nephritis was significantly higher than in patients without nephritis. Of the 24 patients in remission, only one reported allergic rhinitis, and two had positive skin tests for inhalant allergens. We concluded that, although patients with SLE do not have an increased rate of atopic disorders, serum IgE rises during disease activity and is associated with active nephritis. This phenomenon suggests that IgE may be involved in the pathogenesis of SLE, particularly in patients with nephritis.
我们研究了活动性系统性红斑狼疮（SLE）患者血清中疾病活动度与总IgE浓度之间的关系。此外，通过问卷调查以及对24例病情缓解的患者进行常见吸入性过敏原的即时皮肤试验，来调查变应性鼻炎和哮喘的个人及家族病史患病率。在20例活动性疾病患者中，我们发现疾病活动期的IgE浓度显著高于缓解期。这种升高与血清总IgG浓度的升高无关。活动性肾炎患者疾病活动期IgE浓度的升高显著高于无肾炎患者。在24例病情缓解的患者中，只有1例报告有变应性鼻炎，2例吸入性过敏原皮肤试验呈阳性。我们得出结论，尽管SLE患者特应性疾病的发生率没有增加，但疾病活动期血清IgE升高，且与活动性肾炎相关。这一现象表明IgE可能参与了SLE的发病机制，尤其是在肾炎患者中。
