Singhal A, Thomas P, Kearney T, Venugopal S, Serjeant G
Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.
Arch Dis Child. 1995 Mar;72(3):227-9. doi: 10.1136/adc.72.3.227.
Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increases in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS.
纯合子镰状细胞（SS）病中的慢性脾功能亢进显著增加溶血，由此产生的红细胞生成扩张可能具有高昂的代谢成本。SS病脾功能亢进患者行脾切除术后，血液学指标发生显著变化，身高增长速度加快，但体重增长速度未加快。这种模式与治疗后毛首鞭形线虫痢疾综合征中观察到的模式相似，与严重营养不良儿童营养补充后身高和体重增长速度均增加的情况不同。据推测，红细胞生成应激减轻后线性生长加速可能意味着SS病脾肿大儿童存在特定营养素缺乏。
