James W P, Davies H L, Bailes J, Dauncey M J
Lancet. 1978 May 27;1(8074):1122-5. doi: 10.1016/s0140-6736(78)90300-8.
The resting metabolic rates (R.M.R.s) of 69 obese patients were measured during a period of weight stability. All except 4 women had a rate, in megajoules per 24 hours, in excess of that for subjects of normal weight. This increased R.M.R. is obscured by the traditional method of expressing R.M.R. per unit surface area. The high R.M.R. in the obese state was related not to the excess fat but to a 36% and 32% increase in the lean body mass of the men and women respectively. The R.M.R.s of 30 patients measured during weight-loss fell. The increase in R.M.R. in obesity is an important mechanism for achieving energy balance, whereas the progressive fall in R.M.R. during slimming demonstrates the need for a permanent reduction in food intake if energy balance is to be maintained on reaching normal weight. Measuring only the R.M.R. in the obese state is unlikely to help in understanding the pathogenesis of obesity.
在体重稳定期测量了69名肥胖患者的静息代谢率（R.M.R.s）。除4名女性外，所有患者每24小时的代谢率（以兆焦耳计）均超过正常体重受试者。传统的以单位表面积表示R.M.R.的方法掩盖了这种升高的R.M.R.。肥胖状态下较高的R.M.R.并非与多余的脂肪有关，而是分别与男性和女性瘦体重增加36%和32%有关。在体重减轻期间测量的30名患者的R.M.R.s下降。肥胖时R.M.R.的升高是实现能量平衡的重要机制，而减肥期间R.M.R.的逐渐下降表明，如果要在达到正常体重时维持能量平衡，就需要长期减少食物摄入量。仅测量肥胖状态下的R.M.R.不太可能有助于理解肥胖的发病机制。
