Gollapudi S, Sharma H A, Aggarwal S, Byers L D, Ensley H E, Gupta S
Division of Basic & Clinical Immunology, University of California, Irvine 92717, USA.
Biochem Biophys Res Commun. 1995 May 5;210(1):145-51. doi: 10.1006/bbrc.1995.1639.
A polysaccharide (MAR-10) was isolated from the aqueous extract of the plant Hyssop officinalis and examined for its activity against HIV-1 (SF strain) in HUT78 T cell line and primary cultures of peripheral blood mononuclear cells. MAR-10, in a concentration-dependent manner, inhibited HIV-1 replication as demonstrated by the inhibition of HIV-1 p24 antigen and syncytia formation. Furthermore, MAR-10 had no significant direct toxicity or effect on lymphocyte functions or CD4+ and CD8+ T cell counts. In addition, MAR-10 has broad spectrum anti-glycosidase activity. Our study demonstrates that MAR-10 contains strong anti-HIV-1 activity that may be useful in the treatment of patients with HIV-1 infection.
从神香草（Hyssop officinalis）植物的水提取物中分离出一种多糖（MAR-10），并在HUT78 T细胞系和外周血单核细胞原代培养物中检测其对HIV-1（SF株）的活性。MAR-10以浓度依赖的方式抑制HIV-1复制，这通过对HIV-1 p24抗原的抑制和多核巨细胞形成得以证明。此外，MAR-10对淋巴细胞功能或CD4+和CD8+ T细胞计数没有明显的直接毒性或影响。另外，MAR-10具有广谱抗糖苷酶活性。我们的研究表明，MAR-10具有强大的抗HIV-1活性，可能对治疗HIV-1感染患者有用。
