Tátrai E, Adamis Z, Böhm U, Merétey K, Ungváry G
National Institute of Occupational Health, Budapest, Hungary.
J Appl Toxicol. 1995 Jan-Feb;15(1):45-8. doi: 10.1002/jat.2550150110.
Our experiments suggest that in the development of plant dust-induced fibrosing alveobronchiolitis--Scadding's fibrosing alveolitis--the cellulose content of plant dusts has a decisive aetiological role. Namely, the wood dust (pine) and the cellulose induced morphologically identical granulomatous inflammation and fibrosis, whereas the fibre-free extract of wood dust did not cause pathological changes in the lungs. The induction of H2O2 and superoxide anion production, shown in vitro in leucocytes, probably has an important role in the development of fibrosis.
我们的实验表明，在植物粉尘诱导的纤维化肺泡支气管炎（斯卡丁纤维化肺泡炎）的发展过程中，植物粉尘的纤维素含量具有决定性的病因学作用。也就是说，木尘（松木）和纤维素诱导出形态相同的肉芽肿性炎症和纤维化，而木尘的无纤维提取物并未引起肺部的病理变化。体外实验显示，白细胞中过氧化氢和超氧阴离子的产生，可能在纤维化的发展过程中起重要作用。
