Saijo M, Yamamoto M, Saijo H, Fujiyasu H, Takimoto M
Department of Pediatrics, Nayoro City Hospital.
Kansenshogaku Zasshi. 1995 Mar;69(3):316-9. doi: 10.11150/kansenshogakuzasshi1970.69.316.
We report here a case of a 5-month-old infant with thrombocytopenic purpura associated with serologically confirmed primary human herpesvirus-6 (HHV-6) infection. His platelet count decreased to 17,000/mm3 on the 3rd day from the onset: Bone marrow aspiration showed that the megakaryocyte count was 129/mm3 and almost all of the them were of the non-platelet forming type. The IgG antibody to HHV-6 by indirect immunofluorescent assay in the sera in acute and convalescent phases were < 10x and 160x, respectively. IgM antibody to HHV-6 in the acute phase was positive. Platelet-associated IgG was also positive. We diagnosed this case as having thrombocytopenic purpura associated with primary HHV-6 infection. Steroid therapy was started for his thrombocytopenic purpura from the 4th day after the alleviation of his fever. His platelet count increased without side effects and became within the normal range without relapse despite discontinuation of steroid therapy. Thrombocytopenic purpura might be one of the complications of primary HHV-6 infection.
我们在此报告一例5个月大的婴儿，患有血小板减少性紫癜，与血清学确诊的原发性人疱疹病毒6型（HHV - 6）感染相关。发病第3天，他的血小板计数降至17,000/mm³：骨髓穿刺显示巨核细胞计数为129/mm³，几乎所有巨核细胞均为非血小板生成型。急性期和恢复期血清中通过间接免疫荧光法检测的针对HHV - 6的IgG抗体分别<10倍和160倍。急性期针对HHV - 6的IgM抗体呈阳性。血小板相关IgG也呈阳性。我们将此病例诊断为原发性HHV - 6感染相关的血小板减少性紫癜。从发热缓解后的第4天开始，针对他的血小板减少性紫癜进行了类固醇治疗。他的血小板计数升高且无副作用，尽管停用了类固醇治疗，但仍保持在正常范围内且未复发。血小板减少性紫癜可能是原发性HHV - 6感染的并发症之一。
