Rao S M, Binder J R, Hammeke T A, Bandettini P A, Bobholz J A, Frost J A, Myklebust B M, Jacobson R D, Hyde J S
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
Neurology. 1995 May;45(5):919-24. doi: 10.1212/wnl.45.5.919.
We applied functional magnetic resonance imaging (FMRI) to map the somatotopic organization of the primary motor cortex using voluntary movements of the hand, arm, and foot. Eight right-handed healthy subjects performed self-paced, repetitive, flexion/extension movements of the limbs while undergoing echo-planar imaging. Four subjects performed movements of the right fingers and toes, while the remaining subjects performed movements of the right fingers and elbow joint. There was statistically significant functional activity in the left primary motor cortex in all subjects. The pattern of functional activity followed a topographic representation: finger movements resulted in signal intensity changes over the convexity of the left motor cortex, whereas toe movements produced changes either at the interhemispheric fissure or on the dorsolateral surface adjacent to the interhemispheric fissure. Elbow movements overlapped the more medial signal intensity changes observed with finger movements. Functionally active regions were confined to the cortical ribbon and followed the gyral anatomy closely. These findings indicate that FMRI is capable of generating somatotopic maps of the primary motor cortex in individual subjects.
我们应用功能磁共振成像（FMRI），通过手部、手臂和足部的自主运动来绘制初级运动皮层的躯体定位组织图。八名右利手健康受试者在接受回波平面成像时，进行了自主节奏的、重复性的肢体屈伸运动。四名受试者进行右手手指和脚趾的运动，其余受试者进行右手手指和肘关节的运动。所有受试者的左侧初级运动皮层均存在具有统计学意义的功能活动。功能活动模式遵循拓扑表征：手指运动导致左侧运动皮层凸面的信号强度变化，而脚趾运动则在大脑半球间裂处或大脑半球间裂附近的背外侧表面产生变化。肘部运动与手指运动时观察到的更内侧的信号强度变化重叠。功能活跃区域局限于皮质带，并紧密遵循脑回解剖结构。这些发现表明，FMRI能够生成个体受试者初级运动皮层的躯体定位图。
