DNA倍体和ERB - B2癌基因表达在子宫内膜癌预后中的作用。

Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma.

作者信息

Ferrara F, De Santis L, Mangili F, Sassi I, Luchini S, Mandelli C, Santambrogio G, Cantaboni A

机构信息

Cattedra di Anatomia e Istologia Patologica, Università degli Studi di Milano, IRCCS H. San Raffaele, Italy.

出版信息

Pathol Res Pract. 1994 Nov;190(11):1039-43. doi: 10.1016/S0344-0338(11)80899-X.

DOI:10.1016/S0344-0338(11)80899-X

PMID:7746737

Abstract

Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

摘要

本文对73例子宫内膜癌患者进行了回顾性评估。通过免疫组织化学方法，对石蜡包埋组织的分期、分级、肌层浸润深度、流式细胞术DNA倍体以及ERB-B2癌基因表达进行了分析。结果显示，肿瘤的分期与分级之间以及DNA倍体与病程之间存在显著相关性；观察到非整倍体肿瘤患者疾病复发前的时间往往较短。未发现肌层浸润深度与生存率之间存在显著相关性。此外，已表明具有ERB-B2癌基因高表达的肿瘤似乎具有更具侵袭性的进展。