Nylén P, Hagman M, Johnson A C
Department of Neuromedicine, National Institute of Occupational Health, Solna, Sweden.
Pharmacol Toxicol. 1995 Feb;76(2):107-11. doi: 10.1111/j.1600-0773.1995.tb00113.x.
Male pigmented rats (n = 36) were exposed to toluene and/or ethanol (1000 p.p.m. toluene in the inhaled air 21 hr/day, and 5.7-8.0% ethanol in the drinking water continuously) during 8 weeks. Electrophysiological recordings were made 1 week after the exposure. Auditory sensitivity (auditory brainstem response) was reduced only after exposures including toluene. At 20 kHz, ethanol antagonized toluene-induced loss of auditory sensitivity (P < 0.05). Flash evoked potentials were not affected in any group. In peripheral nerve, exposures containing ethanol were followed by increased amplitudes of nerve and muscle action potentials. Exposures including toluene were followed by an increase in liquid consumption.
36只雄性有色大鼠连续8周暴露于甲苯和/或乙醇环境中（吸入空气中甲苯浓度为1000 ppm，每天暴露21小时，饮用水中乙醇浓度为5.7 - 8.0%）。暴露1周后进行电生理记录。仅在包含甲苯的暴露后，听觉敏感性（听觉脑干反应）降低。在20 kHz时，乙醇可拮抗甲苯引起的听觉敏感性丧失（P < 0.05）。任何组的闪光诱发电位均未受影响。在周围神经方面，包含乙醇的暴露后神经和肌肉动作电位幅度增加。包含甲苯的暴露后液体消耗量增加。
