Lazarevic M, Skibinski G, Kelly R W, James K
Department of Surgery (WGH), Wilkie Laboratories, University of Edinburgh Medical School, UK.
Vet Immunol Immunopathol. 1995 Feb;44(3-4):237-50. doi: 10.1016/0165-2427(94)05320-r.
We demonstrate that extracellular secretory vesicles isolated from bovine seminal plasma have immunomodulatory properties. They inhibit mitogen induced proliferation of bovine and human peripheral blood lymphocytes in a dose dependent fashion. They also inhibit phagocytosis of latex particles by bovine neutrophils. Phagocytosis of opsonised Staphylococcus aureus however was not affected. Furthermore phorbol ester and chemotactic peptide induced superoxide production was decreased especially when a suboptimal dose of stimulants was used. We suggest that extracellular secretory vesicles may preserve sperm survival in the female reproductive tract.
我们证明，从牛精浆中分离出的细胞外分泌囊泡具有免疫调节特性。它们以剂量依赖的方式抑制有丝分裂原诱导的牛和人外周血淋巴细胞增殖。它们还抑制牛中性粒细胞对乳胶颗粒的吞噬作用。然而，调理过的金黄色葡萄球菌的吞噬作用不受影响。此外，佛波酯和趋化肽诱导的超氧化物生成减少，尤其是在使用次优剂量的刺激剂时。我们认为，细胞外分泌囊泡可能有助于维持精子在雌性生殖道中的存活。
