Hansson C, Faergemann J
Department of Dermatology, Sahlgrens' Hospital, University of Göteborg, Sweden.
Acta Derm Venereol. 1995 Jan;75(1):31-3. doi: 10.2340/00015555753133.
The effect on the microbial ulcer flora of wet gauze dressings soaked in antiseptic solutions used for desloughing leg ulcers is not known. Quantitative cultures were therefore performed in 45 venous leg ulcers, before application and after 15 minutes' treatment with gauze dressings with four different antiseptic solutions: aluminium acetotartrate (Alsol) 1%, potassium permanganate 0.015%, acetic acid 0.25% and chloramine 0.25%. The percentage of ulcers with each type of microorganism did not differ before and after application of the antiseptic solutions. Staphylococcus aureus was found in 79% of the ulcers, gram-negative rods in 39%, S. epidermidis in 21%, Proteus spp in 21%, Pseudomonas spp in 14% and fungi in none. Potassium permanganate reduced the mean number of bacteria per ulcer from 4.4 x 10(6) to 0.9 x 10(6) (ns), chloramine from 2.7 x 10(6) to 2.2 x 10(6) (ns), Alsol from 1.2 x 10(7) to 3.5 x 10(6) (ns) and acetic acid from 6.3 x 10(6) to 2.6 x 10(5) (p = 0.007). S. aureus was reduced by acetic acid (p = 0.002), gram-negative rods by both chloramine (p = 0.03) and acetic acid (p = 0.03). The number of Pseudomonas, Proteus, S. epidermidis and Streptococcus haemolyticus group G was not reduced significantly (p > 0.05) by any of the solutions.
用于清除腿部溃疡腐肉的浸有防腐溶液的湿纱布敷料对溃疡处微生物菌群的影响尚不清楚。因此，对45例静脉性腿部溃疡进行了定量培养，在使用含有四种不同防腐溶液的纱布敷料治疗前及治疗15分钟后进行：1%酒石酸乙酰铝（Alsol）、0.015%高锰酸钾、0.25%乙酸和0.25%氯胺。应用防腐溶液前后，每种微生物类型的溃疡百分比没有差异。79%的溃疡中发现金黄色葡萄球菌，39%为革兰氏阴性杆菌，21%为表皮葡萄球菌，21%为变形杆菌属，14%为假单胞菌属，未发现真菌。高锰酸钾使每个溃疡的平均细菌数从4.4×10⁶降至0.9×10⁶（无显著性差异），氯胺从2.7×10⁶降至2.2×10⁶（无显著性差异），Alsol从1.2×10⁷降至3.5×10⁶（无显著性差异），乙酸从6.3×10⁶降至2.6×10⁵（p = 0.007）。乙酸使金黄色葡萄球菌数量减少（p = 0.002），氯胺（p = 0.03）和乙酸（p = 0.03）均使革兰氏阴性杆菌数量减少。任何一种溶液对假单胞菌、变形杆菌、表皮葡萄球菌和G群溶血性链球菌数量均未产生显著减少（p > 0.05）。
