5-羟色胺3受体拮抗剂在成瘾及戒断模型中的作用。
The effects of 5-HT3 receptor antagonists in models of dependency and withdrawal.
作者信息
Costall B, Domeney A M, Kelly M E, Naylor R J
机构信息
School of Pharmacy, University of Bradford, West Yorkshire, U.K.
出版信息
Alcohol Alcohol Suppl. 1993;2:269-73.
PMID:7748309
Abstract
Pharmacological manipulations to enhance 5-HT synthesis and release have been reported to reduce alcohol intake. However, recent evidence indicates that 5-HT3 receptor antagonists may also exert a similar effect in a number of species. This report reviews the existing data which implicates a central role for 5-HT3 receptors in the control of psychoactive substance abuse.
摘要
据报道，增强5-羟色胺（5-HT）合成与释放的药理学操作可减少酒精摄入。然而，最近的证据表明，5-HT3受体拮抗剂在许多物种中可能也会产生类似的效果。本报告回顾了现有数据，这些数据表明5-HT3受体在精神活性物质滥用的控制中起核心作用。
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