Oberto J, Drlica K, Rouvière-Yaniv J
Institut de Biologie Physico-Chimique, Paris, France.
Biochimie. 1994;76(10-11):901-8. doi: 10.1016/0300-9084(94)90014-0.
In this review article we present a compilation of the proteins homologous to Escherichia coli HU: the HU-like family. Two of these, HU and IHF from E coli have been extensively characterized genetically and biochemically. Due to their DNA binding activities, these proteins confer a condensed shape to the chromosome and regulate the transcription of selected sets of its genes. The parallel between the dual function of the HU-like proteins and the roles described for eukaryotic histone and HMG proteins is striking, especially in the view that they are evolutionary unrelated.
在这篇综述文章中，我们汇总了与大肠杆菌HU同源的蛋白质：HU样蛋白家族。其中，来自大肠杆菌的HU和IHF这两种蛋白已在遗传学和生物化学方面得到广泛表征。由于它们具有DNA结合活性，这些蛋白质使染色体呈现浓缩形态，并调节其特定基因集的转录。HU样蛋白的双重功能与真核组蛋白和HMG蛋白所发挥的作用之间存在惊人的相似之处，尤其是考虑到它们在进化上并无关联。
