Daneri-Navarro A, Del Toro-Arreola A, Garcia-Velazco J C, Del Toro-Arreola S, Orbach-Arbouys S, Bravo-Cuellar A
Instituto de Patologica Infecciosa Y Experimental "DR Francisco Ruiz Sanchez", Universidad de Guadalajara, Jalisco.
Biomed Pharmacother. 1995;49(1):39-44. doi: 10.1016/0753-3322(96)82576-5.
Lymphoma L-5178-Y bearing Balb/c mice were unable to mount a delayed-type hypersensitivity reaction to dinitrofluorobenzene (DNFB). A suppressor factor present in the ascitis of these mice inhibited the response if given during DNFB sensitization, but not during challenge. The factor was not present in lymphoma-bearing Balb/c nu/nu mice. It appeared to be a 35-66 kDa protein. Non-specific esterase staining indicated that the spleens of tumor-bearing and ascitis-injected mice contained a large excess of macrophages. Our observation that the suppressor factor prevented the very start of the immune response may indicate why immunostimulation is difficult to obtain in cancer bearing hosts.
