Rady P L, Yen A, Rollefson J L, Orengo I, Bruce S, Hughes T K, Tyring S K
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555-1019, USA.
Lancet. 1995 May 27;345(8961):1339-40. doi: 10.1016/s0140-6736(95)92538-4.
Herpesvirus-like DNA sequences (KSHV) have been reported to be associated with various forms of Kaposi's sarcoma (KS). To determine if KSHV was associated with other proliferative skin lesions from non-AIDS immunocompromised patients, 33 skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrhoeic keratosis) from 4 organ-transplant patients receiving immunosuppressive therapy were tested for KSHV by PCR. KSHV sequences were detected in 82% of these skin lesions. Our results suggest that KSHV is associated with lesions other than KS in non-AIDS immunocompromised patients, and may also be involved in the pathogenesis of the various forms of proliferative skin lesions from organ-transplant patients.
据报道，疱疹病毒样DNA序列（卡波西肉瘤相关疱疹病毒）与多种形式的卡波西肉瘤（KS）有关。为了确定卡波西肉瘤相关疱疹病毒是否与非艾滋病免疫功能低下患者的其他增殖性皮肤病变有关，对4名接受免疫抑制治疗的器官移植患者的33处皮肤病变（基底细胞癌、鳞状细胞癌、光化性角化病、寻常疣、非典型鳞状增生和脂溢性角化病）进行了聚合酶链反应检测，以查找卡波西肉瘤相关疱疹病毒。在这些皮肤病变中，82%检测到了卡波西肉瘤相关疱疹病毒序列。我们的结果表明，在非艾滋病免疫功能低下患者中，卡波西肉瘤相关疱疹病毒与卡波西肉瘤以外的病变有关，并且可能也参与了器官移植患者各种形式增殖性皮肤病变的发病机制。
