Abel E L
C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Physiol Behav. 1995 Mar;57(3):611-3. doi: 10.1016/0031-9384(94)00365-c.
Isatin is an endogenous selective inhibitor of monoamine oxidase (MAO) B, related to tribulin, whose activity and excretion in urine is increased during stress and anxiety. A previous study from our laboratory hypothesized that isatin may be a component of an alarm substance that rats secrete in the forced swim test. The present study tested that hypothesis by examining isatin's behavioral effects on open field activity and in the forced swim test. Male rats injected (i.p.) with isatin (0-160 mg/kg) ambulated less in the open field and were more immobile in the forced swim test than controls. These results did not support the hypothesis that alarm substance contains isatin and suggest, instead, that isatin has sedative or anxiolytic activity.
异吲哚酮是一种内源性单胺氧化酶（MAO）B的选择性抑制剂，与刺蒺藜素有关，在应激和焦虑期间其尿液中的活性和排泄量会增加。我们实验室之前的一项研究推测，异吲哚酮可能是大鼠在强迫游泳试验中分泌的一种警报物质的组成成分。本研究通过检测异吲哚酮对旷场活动和强迫游泳试验的行为影响来验证这一假设。腹腔注射异吲哚酮（0 - 160 mg/kg）的雄性大鼠在旷场中的走动比对照组少，并且在强迫游泳试验中比对照组更不动。这些结果不支持警报物质含有异吲哚酮这一假设，相反，表明异吲哚酮具有镇静或抗焦虑活性。
