de Pedro N, Delgado M J, Alonso-Bedate M
Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.
Regul Pept. 1995 Jan 26;55(2):189-95. doi: 10.1016/0167-0115(95)92305-v.
The effect of intraperitoneal or intracerebroventricular beta-endorphin administration on food intake has been studied in satiated goldfish. Food intake was evaluated at different time intervals after injections, 0-2, 2-8 and 0-8 h. The 0.1 and 1 micrograms doses of beta-endorphin intracerebroventricularly administered induced an increase in food intake during the first 2 h postinjection, while no modifications on feeding were observed in the next 6 h. These same doses of beta-endorphin used increased cumulative food intake at 8 h postinjection. In contrast, intraperitoneal injection of 1 micrograms of beta-endorphin did not modify food intake in any of the studied time intervals. Naloxone, an opioid antagonist, attenuated the beta-endorphin-induced feeding increase. These results suggest that opioids may play a role in modulation of feeding central regulation, acting via opioid receptors in goldfish.
已在饱足状态的金鱼中研究了腹腔内或脑室内注射β-内啡肽对食物摄取的影响。在注射后的不同时间间隔（0 - 2小时、2 - 8小时和0 - 8小时）评估食物摄取情况。脑室内注射0.1微克和1微克剂量的β-内啡肽在注射后的前2小时会导致食物摄取增加，而在接下来的6小时内未观察到对进食的影响。注射后8小时，使用的相同剂量的β-内啡肽增加了累积食物摄取量。相比之下，腹腔注射1微克β-内啡肽在任何研究的时间间隔内均未改变食物摄取。阿片类拮抗剂纳洛酮减弱了β-内啡肽诱导的进食增加。这些结果表明，阿片类物质可能通过金鱼体内的阿片受体在调节进食中枢调控中发挥作用。
