De Pedro N, Alonso-Gómez A L, Gancedo B, Delgado M J, Alonso-Bedate M
Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.
Physiol Behav. 1993 Mar;53(3):517-20. doi: 10.1016/0031-9384(93)90146-7.
The effect of intraperitoneal or intracerebroventricular corticotropin-releasing factor (CRF) administration on food intake has been studied in goldfish after 24 h of food deprivation. Food intake was evaluated at different time periods after injection, 0-2, 2-8, and 0-8 h. The 1 and 2 micrograms doses of CRF intracerebroventricularly administered induced a reduction in food intake during the first 2 h, although an increased feeding was observed in the next 6 h. The higher dose of CRF used in this study (3.3 micrograms) increased cumulative food intake at 8 h postinjection. However, intraperitoneal injection of 1 microgram CRF did not modify food intake in any of the studied intervals. These results suggest that CRF may play a role in central regulation of feeding behavior intake in goldfish, and show that CRF effects are time- and dose-dependent.
在金鱼禁食24小时后，研究了腹腔注射或脑室内注射促肾上腺皮质激素释放因子（CRF）对食物摄入量的影响。在注射后的不同时间段（0 - 2小时、2 - 8小时和0 - 8小时）评估食物摄入量。脑室内注射1微克和2微克剂量的CRF在前2小时导致食物摄入量减少，不过在接下来的6小时观察到进食增加。本研究中使用的较高剂量CRF（3.3微克）在注射后8小时增加了累积食物摄入量。然而，腹腔注射1微克CRF在任何研究时间段均未改变食物摄入量。这些结果表明，CRF可能在金鱼摄食行为的中枢调节中发挥作用，并表明CRF的作用具有时间和剂量依赖性。
