Gutiérrez J M, Fernández A, Fueyo A, González C, Fernández S, Menéndez-Patterson A
Departamento de Biología Funcional (Fisiología), Facultad de Medicina, Universidad de Oviedo, Spain.
Rev Esp Fisiol. 1994 Dec;50(4):229-38.
This study evaluates the role of soybean and olive oil in the recovery and evolution of some cardiovascular risk factors in rats undernourished in uterus and during lactation. Beginning at 20 days of age, for a period of 130 days, control (C) and malnourished (M) animals were fed three different diets: standard diet (C, M), standard diet enriched with soybean oil (CS, MS) and standard diet enriched with olive oil (CO, MO). Body weight, systolic and diastolic blood pressure, total cholesterol, HDL-cholesterol and triglycerides levels of pups were measured at periods of 15, 30, 90 and 150 days of age. Malnutrition produced a decreased body weight and experimental diets were ineffective in body weight recovery. The controls, however, displayed overweight. Blood pressure values, taken at different ages and under different diets were within normal limits. Plasma triglycerides increased up to 30 days of age with early undernutrition returning, thereafter, to normal limits. Plasma cholesterol level decreased in all animals with age, except in the CS and CO groups, which showed a significant increase in this parameter at 5 months.
本研究评估了大豆油和橄榄油在子宫内及哺乳期营养不良的大鼠某些心血管危险因素的恢复和演变过程中的作用。从20日龄开始，持续130天，对照（C）组和营养不良（M）组动物分别喂食三种不同的饮食：标准饮食（C、M）、富含大豆油的标准饮食（CS、MS）和富含橄榄油的标准饮食（CO、MO）。在幼崽15、30、90和150日龄时测量其体重、收缩压和舒张压、总胆固醇、高密度脂蛋白胆固醇和甘油三酯水平。营养不良导致体重下降，且实验饮食对体重恢复无效。然而，对照组出现超重。在不同年龄和不同饮食条件下测得的血压值均在正常范围内。血浆甘油三酯在30日龄时因早期营养不良而升高，此后恢复到正常范围。所有动物的血浆胆固醇水平均随年龄增长而下降，但CS组和CO组除外，这两组在5个月时该参数显著升高。
