Lamb G D, Stephenson D G
School of Zoology, La Trobe University, Bundoora, Melbourne, Victoria, Australia.
Biophys J. 1995 Mar;68(3):946-8. doi: 10.1016/S0006-3495(95)80270-5.
Flash photolysis of DM-nitrophen generates an extremely large [Ca2+] transient ("Ca2+ spike") at the start of each Ca2+ "step." The Ca2+ spike greatly increases the speed of activation of the ryanodine receptor channel ("supercharging") and could be responsible for apparent channel adaptation.
二甲基硝基苯酚的闪光光解在每个钙离子“阶梯”开始时会产生一个极大的钙离子瞬变(“钙离子尖峰”)。该钙离子尖峰极大地提高了兰尼碱受体通道的激活速度(“超荷化”),并且可能是通道适应性表现的原因。