Seyoum G, Persaud T V
Department of Anatomy, University of Manitoba, Winnipeg, Canada.
Histol Histopathol. 1995 Jan;10(1):117-25.
For normal fetal growth and development, an ample supply of nutrients and oxygen is essential. The placenta is the conduit for nutrient transfer and thus any factor that alters normal placental structure and function may adversely affect the nutritional status of the fetus. The effect of ethanol ingestion and zinc supplementation on placental structure was investigated by the simultaneous administration of ethanol and zinc to pregnant Sprague-Dawley rats from gestational day 6 through 12. One group of animals was given an ethanol liquid diet, a second group received the ethanol liquid diet plus zinc, and another group was pair-fed a control liquid diet. Placentas were recovered on day 20 of gestation. The mean placental weight in the ethanol group was significantly higher than that in either the pair-fed control or the ethanol plus zinc group. The ethanol-treated group revealed more stagnated blood in the basal-decidual and in the basal-labyrinthine junctions. Intervillous spaces in the labyrinthine zones were markedly dilated and filled with more blood corpuscles compared to the pair-fed control group. The giant cells of the basal zone were also larger in size in the ethanol-treated group. The frequency of occurrence of stagnated blood in either the labyrinthine zone and in the basal-labyrinthine junction was less in the ethanol plus zinc group compared to the ethanol group.
对于正常的胎儿生长发育而言，充足的营养和氧气供应至关重要。胎盘是营养物质转运的通道，因此任何改变正常胎盘结构和功能的因素都可能对胎儿的营养状况产生不利影响。通过从妊娠第6天至12天同时给怀孕的斯普拉格-道利大鼠喂食乙醇和锌，研究了乙醇摄入和锌补充对胎盘结构的影响。一组动物给予乙醇液体饲料，第二组接受乙醇液体饲料加锌，另一组配对喂食对照液体饲料。在妊娠第20天取出胎盘。乙醇组的平均胎盘重量显著高于配对喂食对照组或乙醇加锌组。乙醇处理组在基底蜕膜和基底迷路交界处显示出更多的血液停滞。与配对喂食对照组相比，迷路区的绒毛间隙明显扩张，充满了更多的血细胞。乙醇处理组基底区的巨细胞也更大。与乙醇组相比，乙醇加锌组迷路区和基底迷路交界处血液停滞的发生率更低。
