Hélie P, Drolet R, Germain M C, Bourgault A
Laboratoire de pathologie animale, MAPAQ, Saint-Hyacinthe, Québec.
Can Vet J. 1995 Mar;36(3):150-4.
This purpose of this study was to describe the clinical features and the pathological findings of an unusual condition observed in pigs of a fattening unit in southwestern Quebec. Two of these pigs were submitted for complete postmortem examination. The disease was characterized by a systemic necrotizing vasculitis and an exudative and proliferative glomerulonephritis. In the skin, the vascular lesions produced a conspicuous papular dermatopathy with a characteristic distribution. Bacteriological and virological results were inconclusive. In the glomeruli, there were extensive granular complement deposits with scattered immunoglobulin M. Transmission electron microscopy did not reveal any dense deposits in glomerular basement membrane. The cause of this newly recognized and potentially lethal condition remains unknown, although histological and immunopathological observations suggest an immune-mediated process.
本研究的目的是描述在魁北克西南部一个育肥猪场的猪身上观察到的一种罕见病症的临床特征和病理结果。其中两头猪被送去进行完整的尸检。该疾病的特征为全身性坏死性血管炎和渗出性及增殖性肾小球肾炎。在皮肤上，血管病变产生了具有特征性分布的明显丘疹性皮炎。细菌学和病毒学检测结果不明确。在肾小球中，有广泛的颗粒状补体沉积以及散在的免疫球蛋白M。透射电子显微镜检查未在肾小球基底膜发现任何致密沉积物。尽管组织学和免疫病理学观察提示这是一个免疫介导的过程，但这种新发现的、可能致命的病症的病因仍然不明。
